As Sadie Hawkins Day approaches, Daisy Mae hopes to win the hand of Li’l Abner by catching him in the traditional race. A senator comes to visit to tell the residents of Dogpatch that their town is to be used as an atomic bomb testing ground, unless they can find something necessary about the town. Could Mammy Yokum’s Yokumberry tonic (which Abner has taken every day since he was a baby) be the key?